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The effect of barbiturates on the metabolism of phenytoin appears to be variable. Some investigators report an accelerating effect, while others report anzi che no effect. Because the effect of barbiturates on the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood levels should be monitored more frequently if these drugs are given concurrently.

Use of sedative doses during labor does not impair uterine activity, however, full anesthetic porzione can decrease the force and frequency of uterine contractions.

Phenobarbital sodium is carcinogenic in mice and rats after lifetime administration. Per mezzo di mice, it produced benign and malignant liver cell tumors. Durante rats, benign liver cell tumors were observed very late Per life.

Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations Durante which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.

Abrupt withdrawal of antiseizure medications may increase seizure frequency, withdraw pentobarbital gradually.

Properly treating pentobarbital withdrawal begins when a clinician recognizes the patient is either susceptible to or suffering from withdrawal. When withdrawal is suspected, the interprofessional team must coordinate patient care by:

Pentobarbital also works by inhibiting glutamate, which is responsible for nerve depolarization Con the voltage-activated calcium currents.

Use pentobarbital as ordered by your doctor. Read all information given to you. Follow all instructions closely. It is given as a shot into a muscle or vein. What do I do if I miss a parte?

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If you need to store pentobarbital at home, talk with your doctor, nurse, or pharmacist about how to store it. Consumer Information Use and Disclaimer

4. Compatible with death Con aged or ill persons or Durante presence of obstructed airway, other toxic agents, or exposure to cold.

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